Manchester was born in the Bronx area of New York city to a musical family of Jewish descent. Her father was a bassoonist for the New York Metropolitan Opera. Manchester started a singing career at an early age, learning the piano and harpsichord at the Manhattan School of Music and Arts, singing commercial jingles at age 15, and becoming a staff writer for Chappell Music while attending New York City's High School of the Performing Arts.

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