Una Mae Carlisle was born on December 26, 1915, in Xenia, Ohio. She was "discovered" by Fats Waller late in 1932. He invited her to play on his radio show at station WLW in Cincinnati during Christmas week when Una Mae turned seventeen. She was still in High School at the time, and her mother had approved her Christmas vacation in Cincinnati because she was to stay with her elder sister. When her vacation was over, she refused to return home, becoming a professional musician working with Waller at WLW.

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